Social Network Analysis of Nonprofits in Disaster Response: The Case of Twitter During the COVID-19 Pandemic in the United States

The COVID-19 pandemic has created complex problems that require organizations to collaborate within and across the sector line. Social media data can provide insights into how nonprofits interact for the pandemic response from both social network and geographical perspectives. This study innovatively investigated the connection and interaction patterns among 74 National Voluntary Organizations Active in Disaster (NVOAD) nonprofits and three government agencies based on structural analyses and content analyses of their Twitter communications during the long-term global COVID-19 pandemic. The daily tweeting quantities of all nonprofits were generally consistent with the pandemic severity in the United States before July 2020 and remained stable afterward. Nonprofits’ tweets can reflect their purposes of sharing information, building communities, and taking actions for disaster response. Government agencies played leadership roles in providing COVID-19 guidelines and information. Human services, International and Foreign Affairs, and Public and Societal Benefit nonprofits, especially American Red Cross played central roles in the nonprofit communication network. Possible explanations include the following: (1) Geographically, connections and interactions among nonprofits are more likely to happen within the same city or in neighboring states. (2) Both mission homophily and heterophily contribute to connections and interactions among nonprofits, depending on their subsectors. The findings not only help the public better understand how nonprofits are collaboratively fighting the pandemic, but also provide guidance for nonprofits to plan for better interactions and communications in future disaster response. [ FROM AUTHOR] Copyright of Social Science Computer Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

Rapid Degradation of SARS-CoV-2 Spike S Protein by A Specific Serine Protease.

The S protein of SARS-CoV-2 is a crucial structural and functional component for virus entry. Due to the constant mutation of the virus, there are very limited ways to prevent and control COVID-19. This experiment used a macroscopic SDS-PAGE method and proved that the S protein of wild-type SARS-CoV-2 virus, especially the S1 subunit, is very sensitive to alkaline serine protease with acidic pI (ASPNJ), NJ represents Neanthes japonica (Izuka) from which ASP is purified). ASPNJ cleaves proteins when the carbonyl group of the peptide bond is contributed by arginine or lysine. ASPNJ can degrade the S protein very quickly and effectively in vitro with relative selectivity. It can be inferred that the S, S1 and RBD of SARS-CoV-2 variants can also be easily degraded by ASPNJ. This rapid and strong degradation of the S protein by ASPNJ may become a potential new treatment strategy.

Rapidly measuring spatial accessibility of COVID-19 healthcare resources: a case study of Illinois, USA.

BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing the coronavirus disease 2019 (COVID-19) pandemic, has infected millions of people and caused hundreds of thousands of deaths. While COVID-19 has overwhelmed healthcare resources (e.g., healthcare personnel, testing resources, hospital beds, and ventilators) in a number of countries, limited research has been conducted to understand spatial accessibility of such resources. This study fills this gap by rapidly measuring the spatial accessibility of COVID-19 healthcare resources with a particular focus on Illinois, USA. METHOD: The rapid measurement is achieved by resolving computational intensity of an enhanced two-step floating catchment area (E2SFCA) method through a parallel computing strategy based on cyberGIS (cyber geographic information science and systems). The E2SFCA has two major steps. First, it calculates a bed-to-population ratio for each hospital location. Second, it sums these ratios for residential locations where hospital locations overlap. RESULTS: The comparison of the spatial accessibility measures for COVID-19 patients to those of population at risk identifies which geographic areas need additional healthcare resources to improve access. The results also help delineate the areas that may face a COVID-19-induced shortage of healthcare resources. The Chicagoland, particularly the southern Chicago, shows an additional need for resources. This study also identified vulnerable population residing in the areas with low spatial accessibility in Chicago. CONCLUSION: Rapidly measuring spatial accessibility of healthcare resources provides an improved understanding of how well the healthcare infrastructure is equipped to save people's lives during the COVID-19 pandemic. The findings are relevant for policymakers and public health practitioners to allocate existing healthcare resources or distribute new resources for maximum access to health services.